UNITED STATES  
  SECURITIES AND EXCHANGE COMMISSION  
  Washington, D.C. 20549  

 

SCHEDULE 13G

 

Under the Securities Exchange Act of 1934
(Amendment No. 2)*

 

scPharmaceuticals Inc.

(Name of Issuer)

 

Common Stock, par value $0.0001 per share

(Title of Class of Securities)

 

810648 105

(CUSIP Number)

 

December 31, 2022

(Date of Event Which Requires Filing of this Statement)

 

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

 

¨ Rule 13d-1(b)
x Rule 13d-1(c)
¨ Rule 13d-1(d)

 

*The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

 

The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

 

 

 

 

 

 

CUSIP No. 810648 105
 
  1. Names of Reporting Persons
5AM Ventures IV, L.P.
 
  2. Check the Appropriate Box if a Member of a Group (See Instructions)
    (a) ¨
    (b) x (1)
 
  3. SEC Use Only
 
  4. Citizenship or Place of Organization
Delaware, United States of America
     
Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With
5. Sole Voting Power
0 shares
 
6. Shared Voting Power
 2,231,601 shares (2)
 
7. Sole Dispositive Power
 0 shares
 
8. Shared Dispositive Power
2,231,601 shares (2)
 
  9. Aggregate Amount Beneficially Owned by Each Reporting Person
2,231,601 shares (2)
 
  10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o
 
  11. Percent of Class Represented by Amount in Row (9)
6.6% (3)
 
  12. Type of Reporting Person (See Instructions)
PN
           

(1)This Schedule 13G is filed by 5AM Ventures IV, L.P., a Delaware limited partnership (“Ventures IV”), 5AM Co-Investors IV, L.P., a Delaware limited partnership (“Co-Investors IV”), 5AM Partners IV, LLC, a Delaware limited liability company (“Partners IV”), 5AM Opportunities I, L.P., a Delaware limited partnership (“Opportunities”), 5AM Opportunities I (GP), LLC, a Delaware limited liability company (“Opportunities GP”), Dr. John D. Diekman (“Diekman”), Andrew J. Schwab (“Schwab”), Dr. Kush Parmar (“Parmar”) and Dr. Scott M. Rocklage (“Rocklage”) and together with Ventures IV, Co-Investors IV, Partners IV, Opportunities, Opportunities GP, Diekman, Schwab and Parmar, collectively, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

 

(2)Partners IV serves as the sole general partner of Ventures IV.  Diekman, Schwab and Rocklage are managing members of Partners IV and share voting and dispositive power over the shares held by Ventures IV.  The information with respect to the ownership of the Common Stock by the Reporting Persons filing this statement on Schedule 13G is provided as of December 31, 2022.

 

(3)This percentage is calculated based on 34,022,121 shares of Common Stock outstanding as of November 25, 2022 upon the closing of the Issuer’s public offering, as reported in the prospectus supplement dated November 22, 2022 filed by the Issuer with the Securities and Exchange Commission (the “SEC”) on November 23, 2022.

 

 2 

 

 

CUSIP No. 810648 105
 
  1. Names of Reporting Persons
5AM Co-Investors IV, L.P.
 
  2. Check the Appropriate Box if a Member of a Group (See Instructions)
    (a) ¨
    (b) x (1)
 
  3. SEC Use Only
 
  4. Citizenship or Place of Organization
Delaware, United States of America
     
Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With
5. Sole Voting Power
0 shares
 
6. Shared Voting Power
 92,983 shares  (2)
 
7. Sole Dispositive Power
 0 shares
 
8. Shared Dispositive Power
92,983 shares  (2)
 
  9. Aggregate Amount Beneficially Owned by Each Reporting Person
92,983 of Common Stock (2)
 
  10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o
 
  11. Percent of Class Represented by Amount in Row (9)
0.3% (3)
 
  12. Type of Reporting Person (See Instructions)
PN
           

(1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

 

(2)Partners IV serves as the sole general partner of Co-Investors IV. Diekman, Schwab and Rocklage are managing members of Partners IV and share voting and dispositive power over the shares held by Co-Investors IV. The information with respect to the ownership of the Common Stock by the Reporting Persons filing this statement on Schedule 13G is provided as of December 31, 2022.

 

(3)This percentage is calculated based on 34,022,121 shares of Common Stock outstanding as of November 25, 2022 upon the closing of the Issuer’s public offering, as reported in the prospectus supplement dated November 22, 2022 filed by the Issuer with the SEC on November 23, 2022.

 

 3 

 

 

CUSIP No. 810648 105
 
  1. Names of Reporting Persons
5AM Partners IV, LLC
 
  2. Check the Appropriate Box if a Member of a Group (See Instructions)
    (a) ¨
    (b) x (1)
 
  3. SEC Use Only
 
  4. Citizenship or Place of Organization
Delaware, United States of America
     
Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With
5. Sole Voting Power
0 shares
 
6. Shared Voting Power
 2,324,584 shares (2)
 
7. Sole Dispositive Power
 0 shares
 
8. Shared Dispositive Power
2,324,584 shares (2)
 
  9. Aggregate Amount Beneficially Owned by Each Reporting Person
2,324,584 shares (2)
 
  10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o
 
  11. Percent of Class Represented by Amount in Row (9)
6.8% (3)
 
  12. Type of Reporting Person (See Instructions)
OO
           

(1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

 

(2)Includes 2,231,601 shares of Common Stock held by Ventures IV and 92,983 shares of Common Stock held by Co-Investors IV.  Partners IV serves as the sole general partner of Ventures IV and Co-Investors IV.  Diekman, Schwab and Rocklage are managing members of Partners IV and share voting and dispositive power over the shares held by Ventures IV and Co-Investors IV.  The information with respect to the ownership of the Common Stock by the Reporting Persons filing this statement on Schedule 13G is provided as of December 31, 2022.

 

(3)This percentage is calculated based on 34,022,121 shares of Common Stock outstanding as of November 25, 2022 upon the closing of the Issuer’s public offering, as reported in the prospectus supplement dated November 22, 2022 filed by the Issuer with the SEC on November 23, 2022.

 

 4 

 

 

CUSIP No. 810648 105
 
  1. Names of Reporting Persons
5AM Opportunities I, L.P.
 
  2. Check the Appropriate Box if a Member of a Group (See Instructions)
    (a) ¨
    (b) x (1)
 
  3. SEC Use Only
 
  4. Citizenship or Place of Organization
Delaware, United States of America
     
Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With
5. Sole Voting Power
0 shares
 
6. Shared Voting Power
 410,268 shares (2)
 
7. Sole Dispositive Power
 0 shares
 
8. Shared Dispositive Power
410,268 shares (2)
 
  9. Aggregate Amount Beneficially Owned by Each Reporting Person
410,268 shares (2)
 
  10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o
 
  11. Percent of Class Represented by Amount in Row (9)
1.2% (3)
 
  12. Type of Reporting Person (See Instructions)
PN
           

(1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

 

(2)Opportunities GP serves as the sole general partner of Opportunities.  Schwab and Parmar are managing members of Opportunities GP and share voting and dispositive power over the shares held by Opportunities.  The information with respect to the ownership of the Common Stock by the Reporting Persons filing this statement on Schedule 13G is provided as of December 31, 2022.

 

(3)This percentage is calculated based on 34,022,121 shares of Common Stock outstanding as of November 25, 2022 upon the closing of the Issuer’s public offering, as reported in the prospectus supplement dated November 22, 2022 filed by the Issuer with the SEC on November 23, 2022.

 

 5 

 

 

CUSIP No. 810648 105
 
  1. Names of Reporting Persons
5AM Opportunities I (GP), LLC
 
  2. Check the Appropriate Box if a Member of a Group (See Instructions)
    (a) ¨
    (b) x (1)
 
  3. SEC Use Only
 
  4. Citizenship or Place of Organization
Delaware, United States of America
     
Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With
5. Sole Voting Power
0 shares
 
6. Shared Voting Power
 410,268 shares (2)
 
7. Sole Dispositive Power
 0 shares
 
8. Shared Dispositive Power
410,268 shares (2)
 
  9. Aggregate Amount Beneficially Owned by Each Reporting Person
410,268 shares (2)
 
  10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o
 
  11. Percent of Class Represented by Amount in Row (9)
1.2% (3)
 
  12. Type of Reporting Person (See Instructions)
OO
           

(1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

 

(2)Includes 410,268 shares of Common Stock held by Opportunities.  Opportunities GP serves as the sole general partner of Opportunities. Schwab and Parmar are managing members of Opportunities GP and share voting and dispositive power over the shares held by Opportunities. The information with respect to the ownership of the Common Stock by the Reporting Persons filing this statement on Schedule 13G is provided as of December 31, 2022.

 

(3)This percentage is calculated based on 34,022,121 shares of Common Stock outstanding as of November 25, 2022 upon the closing of the Issuer’s public offering, as reported in the prospectus supplement dated November 22, 2022 filed by the Issuer with the SEC on November 23, 2022.

 

 6 

 

 

CUSIP No. 810648 105
 
  1. Names of Reporting Persons
Dr. John D. Diekman
 
  2. Check the Appropriate Box if a Member of a Group (See Instructions)
    (a) ¨
    (b) x (1)
 
  3. SEC Use Only
 
  4. Citizenship or Place of Organization
United States of America
     
Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With
5. Sole Voting Power
0 shares
 
6. Shared Voting Power
 2,324,584 shares (2)
 
7. Sole Dispositive Power
 0 shares
 
8. Shared Dispositive Power
2,324,584 shares (2)
 
  9. Aggregate Amount Beneficially Owned by Each Reporting Person
2,324,584 shares (2)
 
  10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o
 
  11. Percent of Class Represented by Amount in Row (9)
6.8% (3)
 
  12. Type of Reporting Person (See Instructions)
IN
           

(1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

 

(2)Includes 2,231,601 shares of Common Stock held by Ventures IV and 92,983 shares of Common Stock held by Co-Investors IV.  Partners IV serves as the sole general partner of Ventures IV and Co-Investors IV.  Diekman, Schwab and Rocklage are managing members of Partners IV and share voting and dispositive power over the shares held by Ventures IV and Co-Investors IV.  The information with respect to the ownership of the Common Stock by the Reporting Persons filing this statement on Schedule 13G is provided as of December 31, 2022.

 

(3)This percentage is calculated based on 34,022,121 shares of Common Stock outstanding as of November 25, 2022 upon the closing of the Issuer’s public offering, as reported in the prospectus supplement dated November 22, 2022 filed by the Issuer with the SEC on November 23, 2022.

 

 7 

 

 

CUSIP No. 810648 105
 
  1. Names of Reporting Persons
Andrew J. Schwab
 
  2. Check the Appropriate Box if a Member of a Group (See Instructions)
    (a) ¨
    (b) x (1)
 
  3. SEC Use Only
 
  4. Citizenship or Place of Organization
United States of America
     
Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With
5. Sole Voting Power
0 shares
 
6. Shared Voting Power
 2,734,852 shares (2)
 
7. Sole Dispositive Power
 0 shares
 
8. Shared Dispositive Power
2,734,852 shares (2)
 
  9. Aggregate Amount Beneficially Owned by Each Reporting Person
2,734,852 shares (2)
 
  10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o
 
  11. Percent of Class Represented by Amount in Row (9)
8.0% (3)
 
  12. Type of Reporting Person (See Instructions)
IN
           

(1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

 

(2)Includes 2,231,601 shares of Common Stock held by Ventures IV, 92,983 shares of Common Stock held by Co-Investors IV and 410,268 shares of Common Stock held by Opportunities. Partners IV serves as the sole general partner of Ventures IV and Co-Investors IV. Diekman, Schwab and Rocklage are managing members of Partners IV and share voting and dispositive power over the shares held by Ventures IV and Co-Investors IV.  Opportunities GP serves as the sole general partner of Opportunities. Schwab and Parmar are managing members of Opportunities GP and share voting and dispositive power over the shares held by Opportunities. The information with respect to the ownership of the Common Stock by the Reporting Persons filing this statement on Schedule 13G is provided as of December 31, 2022.

 

(3)This percentage is calculated based on 34,022,121 shares of Common Stock outstanding as of November 25, 2022 upon the closing of the Issuer’s public offering, as reported in the prospectus supplement dated November 22, 2022 filed by the Issuer with the SEC on November 23, 2022.

 

 8 

 

 

CUSIP No. 810648 105
 
  1. Names of Reporting Persons
Dr. Kush Parmar
 
  2. Check the Appropriate Box if a Member of a Group (See Instructions)
    (a) ¨
    (b) x (1)
 
  3. SEC Use Only
 
  4. Citizenship or Place of Organization
United States of America
     
Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With
5. Sole Voting Power
0 shares
 
6. Shared Voting Power
 410,268 shares (2)
 
7. Sole Dispositive Power
 0 shares
 
8. Shared Dispositive Power
410,268 shares (2)
 
  9. Aggregate Amount Beneficially Owned by Each Reporting Person
410,268 shares (2)
 
  10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o
 
  11. Percent of Class Represented by Amount in Row (9)
1.2% (3)
 
  12. Type of Reporting Person (See Instructions)
IN
           

(1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

 

(2)Includes 410,268 shares of Common Stock held by Opportunities.  Opportunities GP serves as the sole general partner of Opportunities. Schwab and Parmar are managing members of Opportunities GP and share voting and dispositive power over the shares held by Opportunities. The information with respect to the ownership of the Common Stock by the Reporting Persons filing this statement on Schedule 13G is provided as of December 31, 2022.

 

(3)This percentage is calculated based on 34,022,121 shares of Common Stock outstanding as of November 25, 2022 upon the closing of the Issuer’s public offering, as reported in the prospectus supplement dated November 22, 2022 filed by the Issuer with the SEC on November 23, 2022.

 

 9 

 

 

CUSIP No. 810648 105
 
  1. Names of Reporting Persons
Dr. Scott M. Rocklage
 
  2. Check the Appropriate Box if a Member of a Group (See Instructions)
    (a) ¨
    (b) x (1)
 
  3. SEC Use Only
 
  4. Citizenship or Place of Organization
United States of America
     
Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With
5. Sole Voting Power
0 shares
 
6. Shared Voting Power
 2,324,584 shares (2)
 
7. Sole Dispositive Power
 0 shares
 
8. Shared Dispositive Power
2,324,584 shares (2)
 
  9. Aggregate Amount Beneficially Owned by Each Reporting Person
2,324,584 shares (2)
 
  10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o
 
  11. Percent of Class Represented by Amount in Row (9)
6.8% (3)
 
  12. Type of Reporting Person (See Instructions)
IN
           

(1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

 

(2)Includes 2,231,601 shares of Common Stock held by Ventures IV and 92,983 shares of Common Stock held by Co-Investors IV. Partners IV serves as the sole general partner of Ventures IV and Co-Investors IV. Diekman, Schwab and Rocklage are managing members of Partners IV and share voting and dispositive power over the shares held by Ventures IV and Co-Investors IV. The information with respect to the ownership of the Common Stock by the Reporting Persons filing this statement on Schedule 13G is provided as of December 31, 2022.

 

(3)This percentage is calculated based on 34,022,121 shares of Common Stock outstanding as of November 25, 2022 upon the closing of the Issuer’s public offering, as reported in the prospectus supplement dated November 22, 2022 filed by the Issuer with the SEC on November 23, 2022.

 

 10 

 

 

Item 1.
  (a) Name of Issuer
scPharmaceuticals Inc.
  (b)

Address of Issuer’s Principal Executive Offices
2400 District Avenue, Suite 310

Burlington, Massachusetts 01830

 
Item 2.
  (a)

Name of Person Filing
5AM Ventures IV, L.P. (“Ventures IV”)

5AM Co-Investors IV, L.P. (“Co-Investors IV”)

5AM Partners IV, LLC (“Partners IV”)

5AM Opportunities I, L.P. (“Opportunites”)

5AM Opportunities I (GP), LLC (“Opportunities GP”)

Dr. John D. Diekman (“Diekman”)

Andrew J. Schwab (“Schwab”)

Dr. Kush Parmar (“Parmar”)

Dr. Scott M. Rocklage (“Rocklage”)

  (b)

Address of Principal Business Office or, if none, Residence
c/o 5AM Ventures

501 Second Street, Suite 350

San Francisco, CA 94107

  (c)

Citizenship

    Entities: 5AM Ventures IV, L.P. - Delaware
      5AM Co-Investors IV, L.P. - Delaware
      5AM Partners IV, LLC - Delaware
      5AM Opportunities I, L.P. - Delaware
      5AM Opportunities I (GP), LLC - Delaware
           
    Individuals: Diekman - United States of America
      Schwab - United States of America
      Parmar - United States of America
      Rocklage - United States of America

 

(d) Title of Class of Securities
Common Stock
  (e) CUSIP Number
810648 105
 
Item 3. If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
  Not applicable.

 

 11 

 

 

Item 4.Ownership

 

Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.

 

Reporting Persons  Shares Held
Directly
   Sole
Voting
Power
   Shared
Voting
Power
   Sole
Dispositive
Power
   Shared
Dispositive
Power
   Beneficial
Ownership
   Percentage
of Class (6)
 
Ventures IV (1) (3)   2,231,601        2,231,601        2,231,601    2,231,601    6.6%
                                    
Co-Investors IV (2) (3)   92,983         92,983         92,983    92,983    0.3%
                                    
Partners IV (1) (2) (3)             2,324,584         2,324,584    2,324,584    6.8%
                                    
Opportunities (4) (5)   410,268         410,268         410,268    410,268    1.2%
                                    
Opportunities GP  (4) (5)             410,268         410,268    410,268    1.2%
                                    
Diekman (1) (2) (3)             2,324,584         2,324,584    2,324,584    6.8%
                                    
Schwab (1) (2) (3) (4) (5)             2,734,852         2,734,852    2,734,852    8.0%
                                    
Parmar (4) (5)             410,268         410,268    410,268    1.2%
                                    
Rocklage (1) (2) (3) (4) (5)             2,324,584         2,324,584    2,324,584    6.8%

 

(1) Includes 2,231,601 shares of Common Stock held by Ventures IV.
(2) Includes 92,983 shares of Common Stock held by Co-Investors IV.
(3) Partners IV serves as the sole general partner of Ventures IV and Co-Investors IV.  Diekman, Schwab and Rocklage are managing members of Partners IV and share voting and dispositive power over the shares held by Ventures IV and Co-Investors IV.
(4) Includes 410,268 shares of Common Stock held by Opportunities.
(5) Opportunities GP serves as the sole general partner of Opportunities. Schwab and Parmar are managing members of Opportunities GP and share voting and dispositive power over the shares held by Opportunities.
(6) This percentage is calculated based on 34,022,121 shares of Common Stock outstanding as of November 25, 2022 upon the closing of the Issuer’s public offering, as reported in the prospectus supplement dated November 22, 2022 filed by the Issuer with the SEC on November 23, 2022.

 

Item 5. Ownership of Five Percent or Less of a Class

 

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following   ☐.

 

Item 6. Ownership of More than Five Percent on Behalf of Another Person
   
  Not applicable.

 

Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person
   
  Not applicable.

 
Item 8. Identification and Classification of Members of the Group
   
  Not applicable.

 

Item 9. Notice of Dissolution of Group
   
  Not applicable.

 

 12 

 

 

Item 10. Certification

 

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having such purpose or effect.

 

Signature

 

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

 

Dated: February 14, 2022

 

5AM Ventures IV, L.P.   5AM Co-Investors IV, L.P.
     
By: 5AM Partners IV, LLC   By: 5AM Partners IV, LLC
its General Partner   its General Partner
     
By: /s/ Andrew J. Schwab   By: /s/ Andrew J. Schwab
  Name: Andrew J. Schwab     Name: Andrew J. Schwab
  Title: Managing Member     Title: Managing Member
     
5AM Partners IV, LLC    
     
By: /s/ Andrew J. Schwab    
  Name: Andrew J. Schwab    
  Title: Managing Member    
     
5AM Opportunities I, L.P.   5AM Opportunities I (GP), LLC
     
By: 5AM Opportunities I (GP), LLC    
its General Partner    
     
By: /s/ Andrew J. Schwab   By: /s/ Andrew J. Schwab
  Name: Andrew J. Schwab     Name: Andrew J. Schwab
  Title: Managing Member     Title: Managing Member
     
  /s/ Dr. John D. Diekman     /s/ Andrew J. Schwab
  Dr. John D. Diekman     Andrew J. Schwab
     
  /s/ Dr. Kush Parmar     /s/ Dr. Scott M. Rocklage
  Dr. Dr. Kush Parmar     Dr. Scott M. Rocklage

 

  ATTENTION  
Intentional misstatements or omissions of fact constitute Federal Criminal Violations (See 18 U.S.C. 1001).

 

 13 

 

 

Exhibit(s):

 

A - Joint Filing Statement

 

 14 

 

 

EXHIBIT A

 

JOINT FILING STATEMENT

 

We, the undersigned, hereby express our agreement that the attached Schedule 13G (or any amendments thereto) relating to the

 

Common Stock of scPharmaceuticals Inc. is filed on behalf of each of us.

 

Dated: February 14, 2022

 

5AM Ventures IV, L.P.   5AM Co-Investors IV, L.P.
     
By: 5AM Partners IV, LLC   By: 5AM Partners IV, LLC
its General Partner   its General Partner
     
By: /s/ Andrew J. Schwab   By: /s/ Andrew J. Schwab
  Name: Andrew J. Schwab     Name: Andrew J. Schwab
  Title: Managing Member     Title: Managing Member
     
5AM Partners IV, LLC    
     
By: /s/ Andrew J. Schwab    
  Name: Andrew J. Schwab    
  Title: Managing Member    
     
5AM Opportunities I, L.P.   5AM Opportunities I (GP), LLC
     
By: 5AM Opportunities I (GP), LLC    
its General Partner    
     
By: /s/ Andrew J. Schwab   By: /s/ Andrew J. Schwab
  Name: Andrew J. Schwab     Name: Andrew J. Schwab
  Title: Managing Member     Title: Managing Member
     
  /s/ Dr. John D. Diekman     /s/ Andrew J. Schwab
  Dr. John D. Diekman     Andrew J. Schwab
     
  /s/ Dr. Kush Parmar     /s/ Dr. Scott M. Rocklage
  Dr. Dr. Kush Parmar     Dr. Scott M. Rocklage

 

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